Analisis Stabilitas Fisik dan Kimia Sediaan Sirup Parasetamol di Suhu Penyimpanan Berbeda (Penelitian laboratorium untuk menilai kestabilan sediaan farmasi berdasarkan kondisi penyimpanan)
DOI:
https://doi.org/10.59585/bajik.v3i3.732Keywords:
Stability, Paracetamol, Syrup, Storage Temperature, SpectrophotometryAbstract
Background: Paracetamol is a widely used antipyretic and analgesic drug, particularly in syrup form for children. The stability of syrup preparations is significantly influenced by storage conditions, particularly temperature.
Objective: This study aimed to analyze the physical and chemical stability of paracetamol syrup preparations stored at different temperatures.
Methods: An experimental laboratory study was conducted on three storage groups: room temperature (25±2°C), cold temperature (4±2°C), and high temperature (40±2°C) for 30 days. Physical stability evaluation included color, clarity, pH, and viscosity, while chemical analysis was performed using UV-Vis spectrophotometry to measure paracetamol levels.
Results: The results showed that syrup stored at high temperatures experienced a significant decrease in active ingredient levels (up to 20%) and changes in pH. Preparations stored at cold and room temperature remained physically and chemically stable throughout the test period.
Conclusion: High storage temperatures accelerate the degradation of paracetamol in syrup preparations, so it is recommended to store at room temperature or refrigerated to maintain stability.
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