Analisis Drug Related Problems (DRPs) pada Pasien Hipertensi di Instalasi Rawat Jalan
Keywords:
Hipertensi, Drug Related Problems, Antihipertensi, Rawat JalanAbstract
ABSTRACT
Hypertension is a chronic disease with a high prevalence in the community and often requires long-term therapy. Inappropriate use of antihypertensive medications can lead to Drug-Related Problems (DRPs), which can potentially reduce the effectiveness of therapy and increase the risk of side effects in patients. This study aims to analyze the incidence of DRPs in hypertensive patients in outpatient settings.
This study used a descriptive, observational method with a retrospective approach through a review of the medical records of hypertensive patients in outpatient settings. Data collected included patient characteristics, the type of antihypertensive medication used, and the incidence of DRPs, including inappropriate medication selection, inappropriate dosage, drug interactions, and side effects.
The results showed that several DRPs were still found in hypertensive patients, including inappropriate medication dosages, potential drug interactions, and inappropriate medication use based on the patient's clinical condition. These DRPs have the potential to impact the success of hypertension therapy.
The conclusion of this study indicates that DRPs still occur in hypertensive patients in outpatient settings. Therefore, the role of healthcare professionals, particularly pharmacists, in monitoring drug therapy is needed to improve the safety and effectiveness of patient treatment.
Keywords: Hypertension, Drug-Related Problems, Antihypertensive, Outpatient
ABSTRAK
Hipertensi merupakan salah satu penyakit kronis yang memiliki prevalensi tinggi di masyarakat dan sering memerlukan terapi jangka panjang. Penggunaan obat antihipertensi yang tidak tepat dapat menyebabkan terjadinya Drug Related Problems (DRPs) yang berpotensi menurunkan efektivitas terapi serta meningkatkan risiko efek samping pada pasien. Penelitian ini bertujuan untuk menganalisis kejadian DRPs pada pasien hipertensi di instalasi rawat jalan.
Penelitian ini menggunakan metode deskriptif observasional dengan pendekatan retrospektif melalui penelaahan rekam medis pasien hipertensi di instalasi rawat jalan. Data yang dikumpulkan meliputi karakteristik pasien, jenis obat antihipertensi yang digunakan, serta kejadian DRPs yang meliputi pemilihan obat yang tidak tepat, dosis yang tidak sesuai, interaksi obat, dan efek samping obat.
Hasil penelitian menunjukkan bahwa masih ditemukan beberapa kejadian DRPs pada pasien hipertensi, di antaranya dosis obat yang tidak sesuai, potensi interaksi obat, serta penggunaan obat yang tidak tepat berdasarkan kondisi klinis pasien. Kejadian DRPs tersebut berpotensi mempengaruhi keberhasilan terapi hipertensi.
Kesimpulan dari penelitian ini menunjukkan bahwa DRPs masih terjadi pada pasien hipertensi di instalasi rawat jalan, sehingga diperlukan peran tenaga kesehatan, khususnya apoteker, dalam melakukan pemantauan terapi obat untuk meningkatkan keamanan dan efektivitas pengobatan pasien.
Kata Kunci: Hipertensi, Drug Related Problems, Antihipertensi, Rawat Jalan
References
Agustiani E. Review drug-related problems in hypertensive patients. Jurnal Biologi Terapan. 2024.
Al-Azzam SI, Alzoubi KH, AbuRuz S, Alefan Q. Drug related problems in outpatients with chronic diseases. Ther Clin Risk Manag. 2020.
Anshila MK, Sreelekshmi BS, Remya V. Evaluation of drug related problems in chronic disease patients in a tertiary care hospital. Int J Health Sci Res. 2020.
Garin N, Sole N, Lucas B, Matas L, Moras D. Drug related problems in clinical practice: prevalence and associated factors. Sci Rep. 2021.
International Journal of Global Health Research. Analysis of drug related problems in geriatric hypertension patients. Int J Glob Health Res. 2024.
Kusumawardani LA, Prasetya H, Nugraha D. Drug-related problems in hypertensive patients: a cross-sectional study. J Res Pharm Pract. 2020.
Mudhofir NS, Rahmawati F, Andayani TM. Evaluasi drug related problems pada terapi antihipertensi di rumah sakit. Jurnal Sains Farmasi. 2025.
Maran, A. A., Alim, A., Marpaung, M. P., Nurhaedah, N., Pannyiwi, R., & Rahmat, R. A. (2023). Edukasi Tentang Pengelolaan Sampah Rumah Tangga Dalam Menjaga Kesehatan Lingkungan Kelurahan Manisa. Sahabat Sosial: Jurnal Pengabdian Masyarakat, 1(4), 241–249. https://doi.org/10.59585/sosisabdimas.v1i4.176
Pramono, E., Fahamsya, A., Awaluddin, A. I., Surya, S., & Pannyiwi, R. (2026). Pengaruh Strategi Lean Management Terhadap Efisiensi Pengelolaan Obat Di Instalasi Farmasi Rumah Sakit. Barongko: Jurnal Ilmu Kesehatan, 4(2), 603–611. https://doi.org/10.59585/bajik.v4i2.1004
Peddi DR, Devi SR, Prasanth D. Evaluation of prevalence and risk factors of drug related problems in chronic diseases. 2023.
Pannyiwi, R., & Ali, A. (2025). Analisis Program Pencegahan dan Faktor Risiko Penyalahgunaan Narkoba pada Remaja: Studi Mixed Method di Kabupaten Sidenreng Rappang. JIMAD : Jurnal Ilmiah Multidisiplin, 2(2), 153–162. https://doi.org/10.59585/jimad.v2i2.859
Rahmat Pannyiwi M. Khalid Fredy Saputra, Nofita Dewi Kok, Supriadin, Arnianti, Iskandar Zulkarnaen, Rosida, (2025). Keperawatan Medikal Bedah: Pendekatan Sistem Tubuh dan Praktik Klinis. Penerbit AGDOSI - ISBN: 978-634-96389-4-4. https://scholar.google.com/citations?view_op=view_citation&hl=id&user=hsoWIbgAAAAJ&pagesize=80&authuser=1&citation_for_view=hsoWIbgAAAAJ:NMxIlDl6LWMC
Saparina T, Wulandari D, Pratiwi A. Identifikasi drug related problems pada pasien hipertensi rawat jalan. Pharmacon. 2023.
Sabbatini AR, Kararigas G. Estrogen-related mechanisms in hypertension and target organ damage. Biol Sex Differ. 2020.
Septiani V, Sutjiatmo AB. Identification of drug related problems in hypertensive patients in outpatient department. BJOP. 2021.
Siahaan M, Purba AV, Silaban G. Association between drug related problems and blood pressure control in hypertensive patients. BJOP. 2023.
Santi, S., Yufuai, A. R., Masding, M., Hanifah, A. N., Yunus, M., Nari, J., Astuti, F., Wahyuni, R., & Pannyiwi, R. (2023). The Role of Midwives in Motivating Mothers to Initiate Early Breastfeeding at Pertiwi Mother and Child Hospital in Makassar City. International Journal of Health Sciences, 1(3), 203–216. https://doi.org/10.59585/ijhs.v1i3.88
Supriatin, S.Kep.,Ners.,M.Kep,(2026). Buku Ajar Etika dan Hukum Keperawatan: Teori, Prinsip dan Praktik. Penerbit AGDOSI - ISBN : 978-634-96747-9-9. https://scholar.google.com/citations?view_op=view_citation&hl=id&user=hsoWIbgAAAAJ&pagesize=80&authuser=1&citation_for_view=hsoWIbgAAAAJ:ldfaerwXgEUC
Tardy AL, Pouteau E, Marquez D. Vitamins and minerals for energy, fatigue and cognition: a narrative review. Nutrients. 2020.
Wijaya D, Nugroho AK, Setiawan E. Drug related problems in hypertensive outpatients: evaluation in clinical practice. Pharmacy Education. 2024.
Yimama M, Jarso H, Desse T. Determinants of drug related problems among hypertensive patients attending hospital clinics. BMC Res Notes. 2021.
Yuliana D, Kartika R, Pramesti D. Evaluation of drug related problems of antihypertensive therapy in outpatient settings. JPNS. 2024.
Zahara R, Rahmawati F, Andayani TM. Drug related problems among hypertensive patients in outpatient clinics. J Clin Pharm Ther. 2022.
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